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current studies
Environmental and Industrial Carcinogenesis > Fuel blends and
oxygenated additives
> Particulate matter
> Ionizing radiation
>Magnetic fields
generated from electric current
> Electromagnetic
fields generated from radio base stations of cellular telephones
Food Additives, Contaminants, Preservatives and Dietary Supplements > Artificial sweeteners
> Natural sweeteners
> Dietary supplements
> Food preservatives
Chemoprevention > Drug therapies
> Natural active
principles
Special Projects > Parkinson's disease
> Blends of artificial
sweeteners
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of traditional Chinese medicine
ricerche in corso
Cancerogenesi Ambientale e Industriale > Miscele di benzina
e additivi ossigenati
> Materiale particolato
> Radiazioni ionizzanti
> Campi magnetici
generati dalla corrente elettrica
> Campi elettromagnetici
generati dalle stazioni radio-base della telefonia mobile
Additivi, Contaminanti, Preservanti e Integratori Alimentari > Dolcificanti artificiali
> Dolcificanti naturali
> Integratori alimentari
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cibi
Chemioprevenzione > Farmaci
> Principi attivi
vegetali
Progetti Speciali > Malattia di Parkinson
> Miscele di dolcificanti
artificiali
> Principi attivi
della medicina tradizionale cinese
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 November 15, 2008
EHP commentary argues the limits of 2-year bioassay exposure regimens: Ramazzini lifespan studies aspartame and toluene cited.
In a recent commentary entitled "The limits of 2-Year Bioassay Exposure Regimens for Identifying Chemical Carcinogens"Environ Health Perspect 116:11, 2008, authors James Huff, Devra Davis and Michael Jacobson argue that the sensitivity of chemical carcinogenesis bioassays would be enhanced by exposing rodents beginning in utero and continuing for 30 months (130 weeks) or until their natural deaths at up to about 3 years. Citing lifespan studies conducted by the European Ramazzini Foundation on aspartame and toluene the authors conclude that observing rodents until their natural deaths (i.e the Ramazzini lifespan model) increases the sensitivity of bioassays, avoids false-negative results, and strengthens the value and validity of results for regulatory agencies.
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