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scientific articles|articoli scientifici

  

  
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  1. Consequences of exposure to carcinogens beginning during developmental life   Order d

    Soffritti M, Belpoggi F, Degli Esposti D, Falcioni L, Bua L. 2008.
    Basic Clin Pharmacol Toxicol 102: 118-124, 2008.

  2. Carcinogenicity of Aspartame: Soffritti responds   View Pdf d

    Soffritti M. 2008.
    Environ Health Perspect 116 A238-A241, 2008.

  3. Il progetto della Fondazione Europea Ramazzini sull’aspartame   View Pdf d

    Soffritti M, Belpoggi F. 2008.
    La Rivista di Scienza dell’Alimentazione, 4: 51-56, 2008.

  4. Aspartame: Soffritti responds   View Pdf d

    Soffritti M. 2007.
    Environ Health Perspect 115 A2-A6, 2007.

  5. Life-span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats   View Pdf d

    Soffritti M, Belpoggi F, Tibaldi E, Degli Esposti D, Lauriola M. 2007.
    Environ Health Perspect 115:1293-1297, 2007

  6. Mesothelioma following asbestos exposure in workers of sugar refinery plants: the Ramazzini Foundation case series   View Pdf d

    Belpoggi F, Soffritti M, Manservigi M, Lauriola M. 2007.
    Eur J Oncol 12: 101-107, 2007

  7. Pleural mesothelioma in a goldsmith exposed to asbestos   View Pdf d

    Soffritti M, Patelli M, Degli Esposti D, Lambertini L, Fornelli A, Belpoggi F. 2007.
    Eur J Oncol 12:41-46, 2007.

  8. Results of long-term carcinogenicity bioassay on Sprague-Dawley rats exposed to aspartame administered in feed   View Pdf d   Order d

    Belpoggi F, Soffritti M, Padovani M, Degli Esposti D, Lauriola M, Minardi F. 2006.
    Ann NY Acad Sci 1076:559-577, 2006.

  9. Results of long-term carcinogenicity bioassays on Coca-Cola administered to Sprague-Dawley rats   View Pdf d   Order d

    Belpoggi F, Soffritti M, Tibaldi E, Falcioni L, Bua L, Trabucco F. 2006.
    Ann NY Acad Sci 1076:736-752, 2006.

  10. Results of a long-term carcinogenicity bioassay on Sprague-Dawley rats exposed to sodium arsenite administered in drinking water   View Pdf d   Order d

    Soffritti M, Belpoggi F, Degli Esposti D, Lambertini L. 2006.
    Ann NY Acad Sci 1076:578-591, 2006.

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November 15, 2008
EHP commentary argues the limits of 2-year bioassay exposure regimens: Ramazzini lifespan studies aspartame and toluene cited.
In a recent commentary entitled "The limits of 2-Year Bioassay Exposure Regimens for Identifying Chemical Carcinogens"Environ Health Perspect 116:11, 2008, authors James Huff, Devra Davis and Michael Jacobson argue that the sensitivity of chemical carcinogenesis bioassays would be enhanced by exposing rodents beginning in utero and continuing for 30 months (130 weeks) or until their natural deaths at up to about 3 years. Citing lifespan studies conducted by the European Ramazzini Foundation on aspartame and toluene the authors conclude that observing rodents until their natural deaths (i.e the Ramazzini lifespan model) increases the sensitivity of bioassays, avoids false-negative results, and strengthens the value and validity of results for regulatory agencies.
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