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scientific articles|articoli scientifici

  

  
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  1. The scientific bases of cancer chemoprevention

    Davis W, Soffritti M, Maltoni C. 1996.
    International Congress Series 1120, 1996.

  2. Methyl-tert-Butyl Ether (MTBE) - a gasoline additive - causes testicular and lymphohaematopoietic cancers in rats   View Pdf d

    Belpoggi F, Soffritti M, Maltoni C. 1995.
    Toxicol Ind Health 11: 119-149, 1995.

  3. Long–term carcinogenicity bioassays on industrial chemicals and man-made mineral fibres, at the Bentivoglio (BT) laboratories of the Bologna Institute of Oncology: premises, programs and results   View Pdf d

    Maltoni C, Minardi F, Soffritti M, Lefemine G. 1991.
    Toxicol Ind Health 7: 63-94, 1991.

  4. La cancerogenesi da talco grezzo contaminato con amianto: primi risultati dei saggi sperimentali dell’Istituto di Oncologia di Bologna [in Italian]   View Pdf d

    Minardi F, Belpoggi F, Franch A, Maltoni C. 1990.
    In: Recenti progressi nelle conoscenze e nel controllo dei tumori. (Triggiani E, Sammarco G, Liguori G, Carretti D, Maltoni C.). Bologna: Monduzzi, 279-293, 1990.

  5. Recent results of carcinogenicity bioassays of fibers and other particulate materials   View Pdf d

    Maltoni C, Minardi F. 1989.
    In: Non-occupational exposure to mineral fibers. (Bignon E, Peto J, Saracci R.) IARC Sci Publ, 90:46-53, 1990.

  6. Living in a Chemical World: occupational and environmental significance of industrial carcinogens   Order d

    1988.
    Ann NY Acad Sci 534, 1988.

  7. Pleural mesotheliomas in Sprague-Dawley rats by erionite: first experimental evidence   View Pdf d

    Maltoni C, Minardi F, Morisi L. 1982.
    Environ Res 29:238-244, 1982.

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November 15, 2008
EHP commentary argues the limits of 2-year bioassay exposure regimens: Ramazzini lifespan studies aspartame and toluene cited.
In a recent commentary entitled "The limits of 2-Year Bioassay Exposure Regimens for Identifying Chemical Carcinogens"Environ Health Perspect 116:11, 2008, authors James Huff, Devra Davis and Michael Jacobson argue that the sensitivity of chemical carcinogenesis bioassays would be enhanced by exposing rodents beginning in utero and continuing for 30 months (130 weeks) or until their natural deaths at up to about 3 years. Citing lifespan studies conducted by the European Ramazzini Foundation on aspartame and toluene the authors conclude that observing rodents until their natural deaths (i.e the Ramazzini lifespan model) increases the sensitivity of bioassays, avoids false-negative results, and strengthens the value and validity of results for regulatory agencies.
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